Endocrine Abstracts

Background: Cardiovascular related deaths account for over 40% of the excess mortality in Turner Syndrome (TS). Hypertension, a modifiable risk factor for both aortic dilatation and dissection, is more commonly encountered in TS during childhood and adolescence. The objective of this systematic review and meta-analysis is to determine the prevalence of hypertension in paediatric patients with TS and in relation to the methodologies of blood pressure evaluation.<p class="ab...

Background: Glucocorticoid treatment is commonly used for Duchenne Muscular Dystrophy (DMD) in young people, but is associated with a high incidence of fragility fractures. This systematic review aims to assess the current evidence for pharmacological and non-pharmacological treatment for osteoporosis in children and adults with DMD, with the goal of guiding future management strategies.Methods: Three online databases (E...

Background: Osteoporosis commonly occurs as a result of long-term glucocorticoid use and muscle weakness in individuals with Duchenne muscular dystrophy (DMD), rendering them highly susceptible to fragility fractures of vertebrae and long bones. Existing clinical guidelines for the management of osteoporosis in DMD primarily focus on paediatric management. In particular, management during transition from paediatric to adult care is not clarified in current int...